Stage Select
3. Crash Bandicoot- As we all know I love this character and would love to see him get into Looney Toons esque shenanigans each week. He's got enough friends and villains that a few seasons bare minimum can work with some fun slapstick.
2. Sly Cooper- My pick for a more serialized show, Sly 2-4 had a formula that would translate well where Sly and his gang would complete a series a missions before setting up a heist to rob a villain. I think doing each heist in 3-4 episode arcs would make for a really fun show.
1. Mass Effect- First off, I know this is M rated but an R rating never stopped Robocop and The Toxic Avenger from getting Saturday morning cartoons. Second, Mass Effect 2 has a pitch for a kids show/cartoon in the Lair of the Shadow Broker DLC. The Shadow Broker has dossiers on all of your party members and Mordin's reveals that in addition to his STG work, he's the Salarian equivalent of Bill Nye with his own show where he teaches science to children. I would watch the hell out of The Very Model of a Scientist Salarian conduct crazy experiments and sing Gilbert and Sullivan to teach science.
Cage Match
Primal Rage comes out sweating, barely able to breathe with a giant beer belly. The crowd is immediately disappointed and worried for how it will fair against anyone, even Bloody Roar. But everyone is left waiting until reminded that Bloody Roar is owned by Konami who won't let it out to play. Primal Rage wins