
When I was growing up, I went to a birthday party with one of my friends from school, and he had a Missile Command arcade machine in his house.
I read that the designers of Missile Command had nightmares about nuclear war while they were making it. Although the 2600 version's documentation painted the game as defending a space colony against an alien invasion, to soften the theme for kids, the cities in the arcade version were meant to represent cities in California (where the designers lived) under Soviet attack.
I played a knockoff of Missile Command written in BASIC, where the cities were cities in Oklahoma.